An overview of tissue and whole organ decellularization processes
نویسندگان
چکیده
منابع مشابه
Optimized protocol for whole organ decellularization
BACKGROUND The idea of tissue decellularization to gain matrices for tissue engineering is promising. The aim of the present study is to establish a safe and reproducible protocol for solid tissue decellularization that prevents the architecture of the matrix with the inherent vascular network. METHODS The study was performed in rat kidneys which were decellularized by a SDS-based perfusion p...
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Renal transplantation is well established as the optimal form of renal replacement therapy but is restricted by the limited pool of organs available for transplantation. The whole organ decellularisation approach is leading the way for a regenerative medicine solution towards bioengineered organ replacements. However, systematic preoptimization of both decellularization and recellularization pa...
متن کاملThe use of whole organ decellularization for the generation of a vascularized liver organoid.
UNLABELLED A major roadblock to successful organ bioengineering is the need for a functional vascular network within the engineered tissue. Here, we describe the fabrication of three-dimensional, naturally derived scaffolds with an intact vascular tree. Livers from different species were perfused with detergent to selectively remove the cellular components of the tissue while preserving the ext...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2011
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2011.01.057